Characterization of depot-specific adipokine release in diet-induced obese mice reveals a distinct secretion profile in paracardial adipose tissue

James R Bell; Paula M Miotto; Helen MM Waddell; Lea MD Delbridge; Matthew J Watt; Magdalene K Montgomery

Journal article

Characterization of depot-specific adipokine release in diet-induced obese mice reveals a distinct secretion profile in paracardial adipose tissue

James R Bell, Paula M Miotto, Helen MM Waddell, Lea MD Delbridge, Matthew J Watt, Magdalene K Montgomery

Scientific Reports | Springer Science and Business Media LLC | Published : 2026

DOI: 10.1038/s41598-026-64158-8

Open access

Abstract

Obesity is characterized by excessive adipose tissue deposition across multiple depots, accompanied by profound alterations in systemic metabolism. Beyond their role in lipid storage, adipose tissues are active endocrine organs that secrete a range of bioactive proteins, i.e., adipokines, that regulate energy homeostasis, inflammation, and metabolic health. Alterations in adipokine secretion are increasingly recognized as key contributors to the development of obesity-related comorbidities. Here, we investigate depot-specific patterns of adipokine release from paracardial (PAT), inguinal (ING), and epididymal (EPI) adipose tissues in healthy lean mice and mice fed a high-fat diet. Using unta..

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University of Melbourne Researchers

DR James Bell Author

Prof Matt Watt Author

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Keywords

Prevention

Diabetes

Nutrition

2.1 Biological and Endogenous Factors

7 Affordable and Clean Energy

Metabolic and Endocrine

31 Biological Sciences

3101 Biochemistry and Cell Biology

32 Biomedical and Clinical Sciences

Obesity